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103404-90-6
Smiles: CC(=O)O/N=C1/C2=CC(Cl)=CC=C2N(CC2=CC(Cl)=CC=C2Cl)C/1=O
N[C@@H](CC1C=CC(=CC=1)[N+]([O-])(CCCl)CCCl)C(O)=O
CAS Number: 1420071-30-2
hypercalcemic type
JIB-04 (NSC693627) - Jumonji Histone Demethylase Inhibitor. CAS# 199596-05-9 0156 103404-90-6JIB 04 (NSC693627, E isomer), CAS No. 199596 05 9, is a potent, selective and cell permeable Jumonji histone demethylase inhibitor. Unlike the other known inhibitors, JIB 04 is not a competitive inhibitor of a ketoglutarate. It inhibits the demethylase activity of Jumonji enzymes in vitro, with IC50 ~230 nM for JARID1A (KDM5A), ~440 nM for JMJD2A (KDM4A) and JMJD2B (KDM4B), ~340 nM for JMJD2E (KDM2E), and ~1 M for JMJD3 (KDM6B) and JMJD2C (KDM4C). JIB
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